Propofol-related infusion syndrome: role of propofol in medical complications of sedated critical care patients.

BACKGROUND Propofol is a popular anesthetic and sedative. Use of propofol has increased manifold in this country over the last decade, and it is most commonly used in intensive care settings. Its rapid action with short half-life, decreased cerebral oxygen consumption, and reduction of intracranial pressure are properties that have made it a favorite in the intensive care unit. Many of these patients are critically ill or injured and require prolonged sedation. Propofol has been associated with morbidity and mortality, and in such cases the question often arises regarding the role propofol plays in these complications. OBJECTIVE To address the issue of propofol-related infusion syndrome and its management. METHOD A hypothetical clinical vignette was created to give a classic presentation of propofol-related infusion syndrome. CONCLUSION It is hoped that this short report will bring more awareness of this entity so that it will be considered in the differential diagnosis in sedated critical care patients.